Solubilities of noble gases (He, Ne, Ar, Kr, and Xe) in mixtures of water + 2,2,2-trifluoroethanol (TFE) at 298.15 K and 101.33 kPa partial pressure of gas are reported. Our procedure for the estimation of these solubilities from the experimental data is described in detail. From these data, the Henry's constants at the vapor pressure of water (the least volatile component), the standard changes in the Gibbs energy for both the solution process and the solvation process, and the so-called excess Henry's constant are calculated. Finally, three prediction methods are applied, and their results are compared and discussed.