화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of the Korean Industrial and Engineering Chemistry, Vol.14, No.3, 253-262, May, 2003
Export Citation
인체 영상용 방사성의약품의 개발
The Development of Radiopharmaceuticals for Human Body Imaging
지대윤†
  • 인하대학교 이과대학 화학과, 인천 402-751
Dae Yoon Chi†
  • Department of Chemistry, Inha University, Inchon 402-751, Korea
E-mail:
초록
삼차원적인 방법으로 인체 영상을 통한 진단법이 개발된 후 형태학적 소견 외에 분자수준의 생화학적 정보를 얻을 수 있는 영상진단법이 요구되어 왔으면 이러한 목적에 부합되는 생화학적 영상진단법으로 단일광자방출전산화단층촬영술(single photon emission computed tomography: SPECT) 및 양전자방출단층촬영술(positron emission tomography: PET)이 개발되어 활용되고 있다. SPECT과 PET 영상진단에 필수적인 요소는 해당 기능을 가진 방사성 동위원소로 표지화된 의약품의 주입이 전제되어야 한다. 이러한 기술을 통하여 인체내의 특정한 장기내의 생화학적 변화를 단백질의 농도 측정을 통해 알 수 있기 때문에 이때 표지화기술과 방사성의약품 개발은 가장 중요한 연구과제가 될 것이다. 이 총설은 방사성의약품을 개발하기 위한 전반적인 개념과 몇가지 실 예를 설명하고자 한다.
After the development of techniques to image the human subjects in a three-dimensional direction, two major techniques-SPECT (Single Photon Emission Computed Tomography) and PET(Positron Emission Temography) have been used widely for imaging of human body to find the biological changes. The mechanism of these two techniques is to detect a single photon or annihilation photons emitted from the subjects injected with radiopharmaceuticals. It may be very important research project to develop selective methods of labeling with radionucildes and to develop new radiopharmaceuticals, because these two techniques can measure the density of receptors, enzymes and transporters in living human. In this paper, the basic concepts for the development of radiopharmaceuticals will be explained how to develop new radiopharmaceuticals including many examples.
Keywords:SPECT;PET;radiopharmaceuticals;human body imaging;radioligands
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