Low-permeability sandstones of the Lower Silurian regional oil and gas accumulation cover about 45,000 mi(2) (117,000 km(2)) of the Appalachian basin and may contain as much as 30 tcf of recoverable gas resources. Major reservoirs consist of the "Clinton" sandstone and Medina Group sandstones. The stratigraphically equivalent Tuscarora Sandstone increases the area of the Lower Silurian regional accumulation (LSRA) by another 30,000 mi(2) (78,000 km(2)). Approximately 8.7 tcf of gas and 400 million bbl of oil have been produced from the Clinton/Medina reservoirs since 1880. The eastern predominantly gas-bearing part of the LSRA is a basin-center gas accumulation, whereas the western part is a conventional oil and gas accumulation with hybrid features of a basin-center accumulation. The basin-center accumulations have pervasive gas saturation, water near irreducible saturation, and generally low fluid pressures. In contrast, the hybrid-conventional accumulations have less-pervasive oil and gas saturation, higher mobile-water saturation, and both normal and abnormally low fluid pressures. High mobile-water saturation in the hybrid-conventional reservoirs form the updip trap for the basin-center gas creating a broad transition zone, tens of miles wide, that has characteristics of both end-member accumulation types. Although the Tuscarora Sandstone part of the basin-center gas accumulation is pervasively saturated with gas, most of its constituent sandstone beds have low porosity and permeability. Commercial gas fields in the Tuscarora Sandstone are trapped in naturally fractured, faulted anticlines. The origin of the LSRA includes (1) generation of oil and gas from Ordovician black shales, (2) vertical migration through an overlying 1000-ft (305-m)-thick Ordovician shale; (3) abnormally high fluid pressure created by oil-to-gas transformation; (4) updip displacement of mobile pore water by overpressured gas; (5) entrapment of pervasive gas in the basin center; (6) postorogenic uplift and erosion, causing gas leakage and a marked reduction in fluid pressure. Most future natural-gas production in the Clinton/Medina sandstones is anticipated to come from the basin-center accumulation. The Tuscarora Sandstone has additional gas resources but typically low reservoir porosity and permeability, and the likelihood of low-energy (in British thermal units) gas reduce the incentive to explore for it.