Biotechnology Progress, Vol.19, No.2, 380-382, 2003
Lipase catalysis in ionic liquids and supercritical carbon dioxide at 150 degrees C
Free and immobilized Candida antarctica lipase B dispersed in ionic liquids (1-ethyl-3-methylimidazolium bistriflimide and 1-buthyl-3-methylimidazolium bistriflimide) were used as catalyst for the continuous kinetic resolution of rac-1-phenylethanol in supercritical carbon dioxide at 120 and 150degreesC and 10 MPa. Excellent activity, stability and enantioselectivity levels were recorded in continuous operation.