The hardware design of reactive distillation (RD) columns pose severe challenges with respect to the choice and design of the hardware;, the requirements of reaction (i.e. high liquid or catalyst holdup) is not in consonance with the requirement of separation (high interfacial area). In this paper we examine an alternative to the RD concept, viz. a distillation column networked with a number of side (external) reactors. If each distillation stage is linked to a side reactor, the performance of the RD column is matched exactly. From a practical point of view it is desirable to reduce the number of side reactors to say 3-6. The precise location of the chosen number of side reactors and the manner in which the liquid draw-offs and reactor effluent re-entry to the distillation column needs to be chosen carefully. We have developed an algorithm to determine the optimum configuration of the side reactor concept in order to maximize conversion. For the case study of methylacetate (MeOAc) production, we see that it is possible to match the conversion level of an RD column by appropriate choice of the number of side reactors and the pump around ratio. The higher the conversion target the larger the number of side reactors and pump around ratios. For modest conversion levels, say <90%, even a three-side reactor configuration will be able to match the performance of the RD column. The study presented here reveals the potential, and limitations, of the side reactor concept for use as an alternative to RD technology. (C) 2003 Elsevier Science B.V. All rights reserved.