A novel multi-tube photoreactor with 0.0188m(3) valid reaction volume was constructed in pilot-scale. This rectangular reactor consisted of 13 regularly distributed silica glass tubes coating with TiO2 thin film photocatalyst. Total active area of TiO2 thin film is 0.3916 m(2). The ratio of surface area to volume achieves 20.8 m(-1). Photocatalytic experiment of phenol red demonstrates that the apparent reaction rate constant (k) is 0.074 65 h(-1) and 0.165 02 h(-1) for reaction system with and without micro-bubbles mixing. The corresponding apparent quantum efficiency (Phi(a)) is 8.1771 x 10(-7) g(.)J(-1) and 4.9036 x 10-7 g.J(-1), respectively. COD value of reactant could decrease to 17mg(.)L(-1) and high performance liquid chromatography (HPLC) only shows two absorption peaks in 24h photocatalytic process time, so this photoreactor has good photomineralization effect. Experimental results reveal that photocatalytic destruction of organics is possible by using the multi-tube photoreactor.