Reaction and crystallization kinetics play an important role in the recovery of enantiomers and polymorphs by crystallization. An approach that couples equilibrium phase behavior and kinetics is proposed for the design of such crystallization processes. A generic model that accounts for reaction, as well as crystal nucleation, growth, and dissolution, kinetics is developed. It allows the process paths to be tracked on phase diagrams and shows the effect of operating policies, design parameters, and kinetic constants on product purity and process productivity. Examples are provided to demonstrate this approach.