Nanoengineered polymeric capsules of different types were deposited on solid supports by the solution casting technique. Patterning of these layers was performed with an electron beam. Electron beam irradiation of such layers resulted in the significant increase of the capsule adhesion to the substrate. Development of the patterns was carried out in detergent solutions under sonication. Capsules in the nonirradiated areas of the samples were washed out, while those in irradiated zones remained on the substrate surface. The possibility of two-step lithography on successively deposited layers of capsules of different types was demonstrated.