An industrial-size airlift loop redox cycle (ALRC) reactor has been designed for the selective oxidation of alcohols. Selective catalytic alcohol oxidation can produce valuable products for fine chemistry applications. However, the catalyst undergoes a factor of 10 loss in activity within hours as a result of overoxidation. The catalyst can be reactivated by contacting it with a reducing environment. This modeling and reactor design study shows that the ALRC reactor is a suitable option for achieving alternating contact of the catalyst with a reducing and oxidizing environment. It is shown that the superficial slurry velocity and the inlet partial pressure of oxygen mainly determine the reactor performance. A reactor design is developed on the basis of kinetic, hydrodynamic, and economic considerations, in which the catalyst activity remains high during its presence in the reactor. Finally, the ALRC reactor is compared with a stirred-tank reactor process involving alternating gas feed streams. It is shown that the ALRC reactor is much cheaper in terms of reactor operation than the stirred-tank reactor process and, thus, this type of reactor can feasibly be used in the selective oxidation of alcohols while maintaining a high catalyst activity.