Pool boiling experiments were conducted in the European Space Agency (ESA) multi-user facility, the bubble, drop, particle unit (BDPU) in the microgravity environment of space. A part of the study involved the heating of a small sphere immersed in R-123 to the onset of nucleate boiling. An analysis of the nucleation process is presented, based on a prior work for so-called quasi-homogeneous nucleation with a flat heater surface in microgravity. Reasonably good qualitative agreement exists between the analysis and measurements. (C) 2003 Elsevier Ltd. All rights reserved.