In this work, we study experimentally the effect of an external osmotic pressure pi(ext) on the swelling of ionic mesoscopic gels in the weak screening limit, where the Debye screening length is larger than the mesh size of the gel. Variations in the osmotic pressure were induced by adding dextran to the solution. The results show that ionic microgels do not respond to pi(ext) below a given value of the normal stress; above this value the system de-swells with increasing osmotic pressure. The start of de-swelling is set by the gel charge density. The Flory thermodynamic theory for ionic gels captures the essential characteristics of the de-swelling behavior; in particular, it predicts with fairly good accuracy the value of pi(ext) at which de-swelling begins. Finally, due to the colloidal character of the gels, we observe that the system flocculates by a depletion interaction mechanism at high dextran concentrations. (C) 2003 American Institute of Physics.