Journal of the American Chemical Society, Vol.125, No.46, 13984-13987, 2003
Kinetic evidence for the existence and mechanism of formation of a barrel stave structure from pore-forming dendrimers
A dendritic approach to the construction of a homologous series of pore-forming amphiphiles has been developed, based on the use of spermidine, spermine, lysine, and cholic acid. A kinetic analysis of Na+ transport across bilayers of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine by three dendritic amphiphiles has provided the strongest evidence to date for a barrel stave structure.