The reaction kinetics of chlorine atoms with the hydrofluoroethers CHF2CF2OCH3 (1), CHF2CF2OCH2CH3 (2), CHF2CF2OCH2CF3 (3), CF3CHFCF2OCH3 (4), and CH2=CHCH2OCF2CHF2 (5) were studied in the gas phase over the temperature range 273-363 K. The experiments were performed at very low pressures (<3 mTorr) in a molecular flow system equipped with a quadrupole mass spectrometer by monitoring both reactants. The proposed Arrhenius expressions for the studied reactions are (in cm(3) molecule(-1) s(-1), 2sigma uncertainties): k(1) = (5.49 +/- 1.51) x 10(-12) exp(-928 +/- 155/T), k(2) = (1.99 +/- 0.12) x 10(-12) exp(-36 +/- 33/T), k(3) = (1.95 +/- 0.72) x 10(-12) exp(-1616 +/- 202/T), k(4) = (8.72 +/- 2.93) x 10(-12) exp(-1112 +/- 186/7), and k(5) = (5.54 +/- 1.96) x 10(-13) exp(821 +/- 214/T). The title reactions proceed via hydrogen atom metathesis, with the exception of the unsaturated CH2=CHCH2OCF2CHF2 ether, where the Cl-atom addition pathway leading to CH2=CHCl is also present. The C-H bond strengths in several hydrofluoroethers were calculated at the B3P86/6-311++G(3df,2p) level of theory, and they show an increase in the order -OCH(CH3)-H < -OCH(CF3)-H < -CH2OCH2-H < -CF2OCH2-H < -OCH2CH2-H < -OCF2CF2-H < -OCF2-H. Furthermore, their room-temperature rate coefficients correlate with the weakest C-H bond strengths in each molecule, according to the expression log(k, in cm(3) molecule(-1) s(-1)) = (23.6 +/- 7.4) - (0.09 +/- 0.02) x [C-H bond strength (in kJ mol(-1))]. In addition, their vertical ionization potentials were calculated at the B3LYP/6-311++G(3df,2p) level of theory, and they also correlate with the room-temperature rate coefficients according to the expression log(k, in cm(3) molecule(-1) s(-1)) = (4.0 +/- 1.7) - (1.42 +/- 0.15) x [ionization potential (in eV)].