We have measured absolute reaction cross sections for the interaction of O+ with ethane, propane, and n-butane at collision energies in the range from near thermal to approximately 20 eV, using the guided-ion beam (GIB) technique. We have also measured product recoil velocity distributions using the GIB time-of-flight (TOF) technique for several product ions at a series of collision energies. The total cross sections for each alkane are in excess of 100 Angstrom(2) at energies below similar to2 eV, and in each case several ionic products arise. The large cross sections suggest reactions that are dominated by large impact parameter collisions, as is consistent with a scenario in which the many products derive from a near-resonant, dissociative charge-transfer process that leads to several fragmentation pathways. The recoil velocities, which indicate product ions with largely thermal velocity distributions, support this picture. Several product ions, most notably the C2H3+ fragment for each of the alkanes, exhibit enhanced reaction efficiency as collision energy increases, which can be largely attributed to endothermic channels within the dissociative charge-transfer mechanism. (C) 2004 American Institute of Physics.