The protonated titanium peroxo complex [Bu4N](4)[HPTi(O-2)W11O39] (1) has been first prepared via interaction of the mu-oxo dimeric heteropolytungstate [Bu4N](8)[(PTiW11O39)(2)O] (3) with an excess of 30% aqueous H2O2 in MeCN. Peroxo complex 1 has been characterized by using elemental analysis, UV-vis, IR, resonance Raman (RR), P-31 and W-183 NMR spectroscopy, cyclic voltammetry, and potentiometric titration. The electronic and vibrational spectra of 1 are very similar to those of the well-known unprotonated titanium peroxo complex [Bu4N](5)[PTi(O-2)W11O39] (2), while P-31 and W-183 NMR spectra differ significantly. A compilation of the physicochemical techniques supports a monomeric Keggin type structure of 1 bearing one peroxo ligand attached to Ti(IV) in a eta(2)-coordination mode. The protonation of the titanium peroxo complex results in an increase of the redox potential of the peroxo group, E-1/2 = 1.25 and 0.88 V relative to Ag/AgCl reference electrode for 1 and 2, respectively. In contrast to 2, 1 readily reacts with 2,3,6-trimethylphenol (TMP) at 40 degreesC in MeCN to give 2,2',3,3',5,5'-hexamethyl-4,4'-biphenoI (BP) and 2,3,5-trimethyl-p-benzoquinone (TMBQ). The proportion between BP and TMBQ in the reaction products depends on the TMP/1 ratio. When a 2-fold excess of TMP is used, the main reaction product is BP (90%), while using a 2-fold excess of 1 leads to TMBQ (95%). On the basis of the product study, a homolytic oxidation mechanism that implicates the formation of phenoxyl radicals is suggested. The RR deuterium labeling experiments show that the activating proton is most likely localized at a Ti-O-W bridging oxygen rather than at the peroxo group. Theoretical calculations carried out at the DFT level on the protonated and unprotonated titanium peroxo derivatives also propose that the most stable complex is formed preferentially after protonation of the Ti-O-W site; however, both Ti-OH-W and TiOO-H protonated anions could coexist in solution.