After a survey that chlorine in CFCs could destroy the ozone filtering out harmful UV radiation was first reported in 1973, UNEP started to regulate the production and usage of ozone-layer-destroying materials. Series of international regulations following Montreal Protocol have accelerated the worldwide innovation activities for the development of alternatives for CFCs. This paper analyzes the Korean endeavor to cope with international regulations of CFCs and investigates the characteristics of the innovation pattern of Korea in the development of CFC alternatives, concentrating on such the domestic usages of Korea as washing agent (wafer, PCB, display et al), refrigerant, forming agent of polymer, and general goods of life.