Characterization of Surface-Modified Poly(DL-lactide-co-glycolide) Scaffolds from Hydrophilic Monomers using Plasma-Enhanced CVD

You Jin Jung; Kweon-Haeng Lee; Chong Won Park; Tae Suk Suh; Choong Man Hong; Seung Hwa Hong; Woong Shick Ahn; Heung Jae Chun

Journal of Industrial and Engineering Chemistry, Vol.11, No.1, 165-169, January, 2005

You Jin Jung, Kweon-Haeng Lee¹, Chong Won Park², Tae Suk Suh, Choong Man Hong³, Seung Hwa Hong³, Woong Shick Ahn, and Heung Jae Chun^†

Department of Biomedical Sciences, Korea
¹Department of Pharmacology, Korea
²Department of Internal Medicine, Colleng of Medicine, Catholic University, Seoul 137-701, Korea
³Blood Products Division, Biologics Evaluation Department, Korea Food and Drug Administration, Seoul 122-704, Korea

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Inductively coupled plasma-assisted chemical vapor deposition (ICP-CVD) at room temperature was used to graft acrylic acid (AAc) and acrylamide (AAm) to a poly(DL-lactic-co-glycolic acid) (PLGA) scaffold surface. The surface of the grafted PLGA scaffolds was characterized by Fourier transform infrared spectroscopy-attenuated total reflectance (FTIR-ATR), electron spectroscopy for chemical analysis (ESCA), and a contact angle meter. The FTIR-ATR spectra of the surface-modified scaffolds showed the characteristic band of PAAc at 1640 cm-1 as well as those of PAAm at 1615 and 1660 cm-1, confirming that the AAc and AAm units were grafted successfully onto the surface of the PLGA scaffolds. The ESCA survey scan, as well as C1s, O1s, and N1s core spectra of the modified surface, also showed that changes in the chemical composition occurred to the surfaces of the grafts. Surface tension of the scaffolds increased to 66.1 dyn/cm as a result of the grafting of the hydrophilic monomers.

Keywords:surface modification;plasma;poly(DL-lactide-co-glycolide);acrylic acid;acrylamide

[References]

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[Referenced By]

[1] Christenson L, Mikos AG, Gibbons DF, Picciolo GL, Tissue Eng., 3, 71 (1997)

[2] Suh SW, Shin JY, Shin J, Kim J, Beak CH, Kim DI, Kim H, Jeon SS, ASAIO J., 48, 460 (2002)

[3] Freed LE, Marquis JC, J. Biomed. Mater. Res., 27, 11 (1993)

[4] Langer R, Vacanti JP, Science, 250, 920 (1993)

[5] Shi G, Cai Q, Wang C, Lu N, Wang S, Bei J, Polym. Adv. Technol., 13, 227 (2002)

[6] Kim BS, Mooney DJ, J. Biomed. Mater. Res., 41, 322 (1997)

[7] Lin HR, Kuo CJ, Yang CY, Shaw SY, Wu YJ, J. Biomed. Mater. Res., 63(3), 271 (2002)

[8] Xs Wu, in Encyclopedic handbook of biomaterials and bioengineering, Part A, Materials, D. L. Wise, D. J. Trantolo, D. E. Altobelli, M. J. Yaszemski, J. D. Gresser, and E. R. Schwartz Eds,. vol. 2, pp. 1015-1054, Marcel Dekker, New York (1995)

[9] Oh SH, Kang SG, Kim ES, Cho SH, Lee JH, Biomaterials, 24, 4011 (2003)

[10] Mikos AG, Thorsen AJ, Czerwonka LA, Bao Y, Langer R, Winslow DN, Vacanti JP, Polymer, 35(5), 1068 (1994)

[11] Lee HY, Lee DK, Kang DH, Lee JJ, Joo JH, Surf. Coat. Technol., In Press, Corrected Proof, Available online 27 September (2004)

[12] Lee BK, Lee YS, Chong YB, Choi JB, Rho JS, J. Ind. Eng. Chem., 9(4), 426 (2003)

[13] Hong KC, Kim JH, Bae JY, J. Ind. Eng. Chem., 9(6), 693 (2003)

[14] Kwon OH, Nho YC, Lee YM, J. Ind. Eng. Chem., 9(2), 138 (2003)

[15] Owens D, J. Appl. Polym. Sci., 13, 1711 (1969)

[16] Chun HJ, Cho SM, Lee YM, Lee HK, Suh TS, Shinn KS, J. Appl. Polym. Sci., 72(2), 251 (1999)

[17] Suh TS, Joo CK, Kim YC, Lee MS, Lee HK, Choe BY, Chun HJ, J. Appl. Polym. Sci., 85(11), 2361 (2002)

[18] Martinez-Sancho C, Herrero-Vanrell R, Negro S, J. Control. Release, 99(1), 41 (2004)

[19] Beamson G, Briggs D, In High Resolution XPS of Organic Polymers, John Wiley & Sons, Chichester (1992)