The Ion-exchange Kinetics of SAM+/H+ System with JK110 Resin

Yong Chen; Zhinan Xu; Wenhe Shen; Jianping Lin; Peilin Cen

Korean Journal of Chemical Engineering, Vol.22, No.1, 121-126, January, 2005

DOI10.1007/BF02701473 Export Citation

The Ion-exchange Kinetics of SAM+/H+ System with JK110 Resin

Yong Chen, Zhinan Xu¹, Wenhe Shen¹, Jianping Lin¹, and Peilin Cen^{1, †}

Pharmaceutical Informatics Institute, Department of Chinese Medicine Science & Engineering, Zhejiang University, Hangzhou 310027, China
¹Institute of Bioengineering, Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou 310027, China

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S-adenosyl-L-methionine (SAM) is an important small molecule with many medical interests. The ionexchange kinetics of SAM+/H+ system with JK110 resin has been studied in this work. The results showed that intraparticle diffusion was the rate limiting step in the ion-exchange process. A suitable model of particle diffusion has been proposed to describe the effects of pH, temperature and SAM concentration in the solution on the ion-exchange rate. By simulating experimental data with model equation, some parameters such as diffusion constant B, internal diffusion coefficient Di and activation energy Ea are obtained.

Keywords:S-adenosyl-L-methionine Separation;JK110 Resin;Exchange Velocity;Particle Diffusion Model

[References]

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Alessandra M, Lernia ID, Carteni M, Rose RD, Int. J. Pharm., 194, 61 (2000)
Anderer P, Saletu B, Semlitsch HV, Int. Congress Series, 1232, 237 (2002)
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Ftiedel HA, Goa KL, Benfield P, Drugs, 38, 389 (1989)
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Giulidori P, Galli-Kienle M, Katio E, Stramentinoli G, J. Biol. Chem., 259, 4205 (1984)
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Lu SC, Int. J. Biochem. Cell Biol., 32, 391 (2000)
Mato JM, Alvarez L, Ortiz P, Pharmacology Therapeutics, 73, 265 (1997)
Pascale RM, Marras V, Simile MM, Daino L, Pinna G, Bennati S, Carta M, Seddaiu MA, Massarelli G, Feo F, Cancer Res., 52, 4979 (1992)
Rengaraj S, Kim Y, Joo CK, Choi K, Yi J, Korean J. Chem. Eng., 21(1), 187 (2004)
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Wei W, Kramer PM, Siming Y, J. Chromatogr. B, 762, 59 (2001)
Yue TS, Wang YJ, J. Lanzhou University, 36, 67 (2000)

[Referenced By]

[1] Alessandra M, Paola S, Giovanni C, Monica L, Maria C, Mario DR, Biochimica et Biophysica Acta, 1573, 105 (2002)

[2] Alessandra M, Lernia ID, Carteni M, Rose RD, Int. J. Pharm., 194, 61 (2000)

[3] Anderer P, Saletu B, Semlitsch HV, Int. Congress Series, 1232, 237 (2002)

[4] Boyd GE, Adamson AW, Myers LS, J. Am. Chem. Soc., 69, 2836 (1947)

[5] Charles SL, J. Hepatol., 30, 1155 (1999)

[6] Fiecchi, Alberto, US patent, 4028183 (1977)

[7] Ftiedel HA, Goa KL, Benfield P, Drugs, 38, 389 (1989)

[8] Farooqui J, Kim S, Paik WK, Electroanalysis, 4, 261 (1983)

[9] Giulidori P, Galli-Kienle M, Katio E, Stramentinoli G, J. Biol. Chem., 259, 4205 (1984)

[10] Hoffman JL, Biochemistry, 25, 4444 (1986)

[11] Hui L, "Techniques and Mechanism of the Co-production of S-Ade-nosyl-L-methionine and Glutathione using the Yeast" (Doctor Dissertation), Hangzhou: College of Materials Science and Chemical Engineering, Zhejiang University (2002)

[12] Lu SC, Int. J. Biochem. Cell Biol., 32, 391 (2000)

[13] Mato JM, Alvarez L, Ortiz P, Pharmacology Therapeutics, 73, 265 (1997)

[14] Pascale RM, Marras V, Simile MM, Daino L, Pinna G, Bennati S, Carta M, Seddaiu MA, Massarelli G, Feo F, Cancer Res., 52, 4979 (1992)

[15] Rengaraj S, Kim Y, Joo CK, Choi K, Yi J, Korean J. Chem. Eng., 21(1), 187 (2004)

[16] Vettere G, Am. J. Med., 83, 78 (1987)

[17] Wei W, Kramer PM, Siming Y, J. Chromatogr. B, 762, 59 (2001)

[18] Yue TS, Wang YJ, J. Lanzhou University, 36, 67 (2000)