Biotechnology Letters, Vol.26, No.3, 235-238, 2004
Nisin production by Lactococcus lactis subsp lactis under nutritional limitation in fed-batch culture
Nisin production was improved under nutritional limitation in fed-batch culture of Lactococcus lactis. Nisin titre reached 3887 IU ml(-1) by a slow feeding of sucrose and 4131 IU ml(-1) by slow feeding of nitrogen source, which were, respectively, 64% and 74% above the values in batch culture.