Titanium silicalite-1 monolith (TS-1M) was prepared using polyurethane foam as the template. The characterization of the TS-1M was carried out using XRD, SEM, UV-vis and FT-IR spectroscopies, and water vapor adsorption. Catalytic activity was measured for 1-hexene and 2,5-dihydrofuran epoxidation using H2O2 as an oxidant. These studies revealed that TS-1 monoliths have essentially identical chemical properties to the TS-1 powders, but the crystal morphology was different and diffusion plays an important role in the catalysis of the liquid-phase epoxidation reactions.