In this paper, a generalized model of the reactive distillation processes was developed via rate-based approach. The homotopy-continuation method was employed to solve the complicated nonlinear model equations efficiently. The simulation on the reactive distillation processes was carried out with the profiles of stage temperature, composition and How rate for both vapor and liquid phases obtained. Based on careful analysis of the simulation results, the pitfalls in experimental design were detected. Finally, a software package for the simulation of reactive distillation processes was developed.