A new model based on the theoretical work of Boudh-Hir and Mansoori was developed for prediction of surface tension of pure fluids. The new model has the advantage of not requiring densities in the calculation, and the input parameters are critical temperature and connectivity indices. A total of 209 compounds covering a wide variety of substances were used to develop the model, and the overall correlative AAD is 4.21%. To test its predictive ability, the model is further used to predict the surface tension of 25 more compounds that were not included in the model development. The overall predictive AAD is 4.07%, which illustrates that the model is reliable. The model proposed is simple and easy to apply, with good predictive accuracy.