Broadband dielectric spectroscopy (10(-2)-10(9) Hz) and temperature-modulated differential scanning calorimetry have been performed to study the molecular dynamics of monomer, dimer, and trimer of propylene glycol mono methyl ether (PGME) confined in a two-dimensional layer-structured Na-vermiculite clay. A slight speeding up of the main alpha relaxation due to the confinement is observed, while the secondary and more local beta relaxation is unaffected by the confinement. It was also found that the fragility increased with increasing M-w in both bulk and confined samples. These effects can be attributed to the network formation via hydrogen bonds. We also found indications for a low-dimensional character of the correlation volume involved in the glass transition of PGME and its oligomers.