This article investigates the role of solvation effects in the autocatalysis reaction of the epoxy-amine cure reaction. A single-phase three component model was developed encompassing a two-component reaction mix and a single polymeric product. The reaction was modelled as an S(N)2 reaction. Association of the nucleophile with each component in the reaction was defined via a binding constant. (C) 2004 Wiley Periodicals, Inc.