Nanoparticle fluidization was studied in a centrifugal fluidized bed (CenFB) with variable gravitational acceleration (Gg) conditions. Agglomerate size variation in CenFB nanoparticles (7 nm) was examined with G and fluidization time. With increasing fluidization time, the agglomerate size was found to decrease and reach an equilibrium value after several hours. Higher G reduced agglomerate size. To elucidate these phenomena, a comprehensive model was developed based on the energy balance model with respect to energy consumption for disintegration of agglomerates. Experimental results showed good agreement with the proposed model. Effects of high G on agglomerate fluidization are clarified as follows. The critical minimum size of agglomerates, which is the agglomerate size estimated by the force balance model, is reduced by high G. Attainable energy for disintegration of agglomerates is increased, leading to decreased agglomerate size. (C) 2004 American Institute of Chemical Engineers.