The present work is aimed at building a comprehensive heat transfer model for pool boiling on horizontal tubes combining sliding bubble mechanism with natural convection, microlayer evaporation and transient conduction during boundary layer reformation, to predict the boiling heat flux for a given wall superheat. The model has been compared to experimental results from literature for R134a and also to independent experiments conducted by the authors for water. Even with a number of simplified assumptions a reasonably good agreement has been observed between model and experiments in the low and medium heat flux region and moderate pressure.