Chinese Journal of Chemical Engineering, Vol.12, No.4, 521-526, 2004
Studies on partial molar volumes of some amino acids and their groups in aqueous solutions from 293.15 K to 333.15 K
Densities of aqueous solutions of eight amino acids, glycine, L-alanine, L-valine, L-isoleucine, L-serine, L-threonine, L-arginine and L-phenylalanine, are measured as a function of amino acid concentration from 293.15 K to 333.15 K. These data are used to calculate the apparent molar volume V-phi and infinite dilution apparent molar volume V-phi(0) (partial molar volume). Data of five amino acids are used to correlate partial molar volume V-phi(0) using group contribution method to estimate the contributions of the zwitterionic end groups (NH3+,COO-) and CH2 group, OH group, CNHNHNH2 group and C6H5(phenyl) group of amino acids. The results show that V-phi(0) values for all kinds of groups of amino acids studied increase with increase of temperature except those for CH2 group, which are almost constant within the studied temperature range. Data of other amino acids, L-valine, L-isoleucine and L-threonine, are chosen for comparison with the predicted partial molar volume V-phi(0) using the group additivity parameters obtained. The results confirm that this group additivity method has excellent predictive utility. Keywords partial molar volume, amino acid, group contribution.