Almost in all the major cities in Asian countries, residential buildings are characterized with high-rise and high density. Under this circumstance, achieving comfortable and healthy indoor environment with minimized energy consumption becomes a very challenging engineering and societal issue. While the wide use of air-conditioning helped to improve thermal comfort, health problems associated with poor indoor air qualities have appeared more frequently. The increased energy consumption is also a great concern in view of its impact on the energy economics of the region. Drawn from some of the onsite measurements and survey, and also the author's personal observation, some of the key issues are discussed in this paper. (C) 2004 Elsevier B.V. All rights reserved.