A model based on a combination of the solubility parameters of Hansen and the polymer solution theory of Flory-Rehner was used to predict the solubility and permeation properties of organic solvents in Viton polymeric glove material. To test the validity of the model, weight gain data were collected for 32 organic solvents versus Viton. Samples were exposed for periods of 2 to 12 weeks until each glove sample had achieved a stable, equilibrium weight. Using a nonlinear least-squares regression, the three-dimensional solubility parameter was determined for Viton to be as follows: dispersion = 15.38, polar = 10.49, and hydrogen bonding = 2.47. Breakthrough times, lag times, and steady-state permeation rates for the solvents verses Viton were also determined and combined with results obtained from the literature. A high level of correlation was observed between the model and the properties evaluated. (C) 2004 Wiley Periodicals, Inc.