The reaction kinetics for anaerobic biodegradation of volatile acid components, including acetic, propionic and butyric acids commonly contained in the wastewater from beer brewery factories, was investigated in a granular sludge bed. For the degradation of each single substrate component in the granular sludge bed reactor, the reaction scheme was specified and the Monod kinetic parameters were evaluated. In addition, the degradation sequences and their kinetics were also identified for multiple substrate systems with combinations of the three volatile acid components including acetic, propionic and butyric acids. The batch degradation sequences for the single and multiple substrates in the batch sludge bed reactor were explained well by the numerical solutions of multiple differential mass balance equations for the components involved on the basis of the Mound kinetics associated with or without competitive and non-competitive inhibition mechanisms for the specified combinations of the substrate components.