Explicit internal signal stochastic resonance (EISSR) is investigated in a model of energy transduction of molecular machinery when noise is added to the region of oscillation in the presence of external signal (ES). It is found that EISSR could be controlled, i.e., enhanced or suppressed by adjusting frequency (omega(e)) and amplitude (A) of ES, and that there exits an optimal frequency for ES, which makes EISSR strength reach the maximum. Meanwhile, a critical amplitude (A(c)) is found, which is a threshold of occurrence of EISSR. Finally, the difference and similarity between EISSR and IISSR (implicit internal signal stochastic resonance) are discussed. (C) 2004 American Institute of Physics.