Classically, sinusoidal oscillations are imposed to enhance mixing and mass transfer between two phases contacted. But, in any case of solid-liquid contact, it was noticed that this pulsation mode was not efficient enough to allow a controlled behavior of the solid phase. The problem is particularly met during the treatment of raw plants or polydispersed populations with complex physical properties. The objective of this study is to demonstrate the viability of using a nonsinusoidal pulsation in a continuous contactor to replace a traditional batch sinusoidal mode. A review of the different pulsation techniques is firstly presented. The example of solid-liquid extraction of andrographolide from plants has then been chosen to bring out the advantages of the new pulsation mode. The development of this application as a continuous process in a column has indeed encountered difficulties due to the important heterogeneity of the matter: one of these classes tends to float and the other to sink, which always leads to a definitive flooding in classical operations. Typically, the proposed signal is composed of two different periods: on the one hand, a classical sinusoidal pulsation step used to mix the liquid and solid phases in the active part of the column and allowing an optimal mass transfer and, on the other hand, an impulsion phase, generally used for the transport of solid. The extraction is carried out in a disk and doughnut column of 54 mm in diameter and 3.5 m in height. Liquid and solid are flowing concurrently and downwardly. Experiments have been performed to know the global characteristics of the process in steady state and to suggest some elements for industrial design. The results showed that an optimal tuning of the geometric characteristics of the column, the level of interface and the parameters of the pulsation could increase the operated domain where flooding is avoided.