This study reports a numerical approach for modeling the hydraulic resistance of a filter cake of deformable cells. First, a mechanical and osmotic model that describes the volume fraction of solids in a bed of yeast cells as a function of the compressive pressure it experiences is presented. The effects of pressure on the compressibility of yeast cells beds were further investigated both by filtration experiments and by centrifugal experiments based on the multiple speed equilibrium sediment height technique. When comparing the latter measurements with compression model calculations, we observed that the method based on centrifugal experiments suffers from rapid relaxation of the compressed bed. Concerning the filtration experiments, specific resistance of well-defined bed of cells were calculated by a combination of the compression model with a formulation for hydraulic resistivity developed using the Lattice Boltzmann method. We further explain the experimental values observed for the hydraulic resistance of cell beds, assuming that the first layer of cells in contact with the membrane partially blocks the membrane area open to flow. In such a case, the blocked area seems to be a constant fraction of the normal cell-cell contact area. (C) 2004 Elsevier Ltd. All rights reserved.