A robust nonlinear predictive control strategy using a disturbance estimator is presented. The disturbance estimator is comprised of two parts : one is the disturbance model parameter adaptation and the other is future disturbance prediction. A linear discrete model is proposed as a disturbance model which is formulated by using process inputs and available process measurements. The recursive least square (RLS) method with exponential forgetting is used to determine the uncertain disturbance model parameters and for the future disturbance prediction, future disturbances projected by the future process inputs are used. Two illustrative examples : a jacketed CSTR as a SISO system : an adiabatic CSTR as a MIMO system, and experimental results of the distillation column control are presented. The results indicate that a substantial improvement in nonlinear predictive control performance is possible using the disturbance estimator.