The paper is aimed at defining the best option of a combination of electrochemical and biological processes for tannery wastewater treatment. Kinetic data for the electrochemical process are derived from an extensive experimental study, while those relating to biological processes are taken from the authors previously published studies or from the literature. Four different options based on a combination of electrochemical oxidation and biological treatment are defined and compared with the traditional tannery wastewater treatment with respect to the total required volume, energy need and the quantity of generated sludge.