The substrate and field dependencies of surface SPINOE enhancements using optical pumping and magic angle spinning NMR were monitored. Relaxation rates and enhancements were examined to gain an understanding of the parameters that determine the SPINOE enhancement. C-13-labeled deuterated methanol was adsorbed on three different substrates (SnO2, TiO2, Ti/SiO2) with heats of adsorption for xenon ranging from 14.2 to 22.6 kJ/mol. The different heats of adsorption led to a range of xenon coverages and xenon relaxation rates. Using a simple model along with experimental values for the xenon surface polarization and cross- and self-relaxation rates, the C-13 signal enhancement could be predicted and compared with experimental enhancement values. Magnetic field dependence studies were also made by monitoring the C-13 enhancements via SPINOE from hyperpolarized xenon at fields of 0.075, 4.7, and 9.4 T. The pertinent parameters necessary to achieve maximum SPINOE enhancement are discussed.