화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.13, No.3, 167-175, June, 2005
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Self-Assembled Nanoparticles of Bile Acid-Modified Glycol Chitosans and Their Applications for Cancer Therapy
Kwangmeyung Kim1, 2, Jong-Ho Kim1, 2, Sungwon Kim1, Hesson Chung1, Kuiwon Choi1, Ick Chan Kwon1, 2, Jae Hyung Park3, †, Yoo-Shin Kim4, 5, Rang-Won Park4, 5, In-San Kim4, 5, and Seo Young Jeong6
  • 1Biomedical Research Center, Korea Institute of Science and Technology, Seoul 136-791, Korea
  • 2KIST Regional Laboratory in Advanced Medical Technology Cluster for Diagnosis & Prediction, Daegu 700-422, Korea
  • 3Department of Advanced Polymer and Fiber Materials, College of Environment and Applied Chemistry, Kyung Hee University, Gyeonggi-do 449-701, Korea
  • 4Department of Biochemistry, School of Medicine, Kyungpook National University, Daegu 700-422, Korea
  • 5Advanced Medical Technology Cluster for Diagnosis & Prediction, Daegu 700-422, Korea
  • 6Department of Pharmaceutics, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea
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This review explores recent works involving the use of the self-assembled nanoparticles of bile acid-modified glycol chitosans (BGCs) as a new drug carrier for cancer therapy. BGC nanoparticles were produced by chemically grafting different bile acids through the use of 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). The precise control of the size, structure, and hydrophobicity of the various BGC nanoparticles could be achieved by grafting different amounts of bile acids. The BGC nanoparticles so produced formed nanoparticles ranging in size from 210 to 850 nm in phosphate-buffered saline (PBS, pH=7.4), which exhibited substantially lower critical aggregation concentrations (0.038-0.260 mg/mL) than those of other low-molecular-weight surfactants, indicating that they possess high thermodynamic stability. The BGC nanoparticles could encapsulate small molecular peptides and hydrophobic anticancer drugs with a high loading efficiency and release them in a sustained manner. This review also highlights the biodistribution of the BGC nanoparticles, in order to demonstrate their accumulation in the tumor tissue, by utilizing the enhanced permeability and retention (EPR) effect. The different approaches used to optimize the delivery of drugs to treat cancer are also described in the last section.
Keywords:glycol chitosan;nanoparticle;EPR effect;cancer therapy
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