We compared the immunomodulating effects of Phellinus linteus (PL), germinated brown rice ( BR) and P. linteus grown on germinated brown rice (PB) on IgE production in murine mesenteric lymph node (MLN) lymphocytes. All extracts decreased IgE concentrations by 43 - 65% compared to control mice in both serum and MLN lymphocytes. In addition, PL and PB increased the proportion of CD4(+) T cells by 9% and 12% in MLN lymphocytes. IFN-gamma concentration, Th1 cytokine, was significantly increased by 44 - 67%, whereas IL-4 and IL-10 concentrations, Th2 cytokine, significantly decreased by 30 - 60% in the three treated groups compared to control group. These results suggest that PB suppresses IgE production through the modulation of Th1/Th2 balance to down-regulate Th2 response in MLN lymphocytes, even though a synergistic effect of PB was not found.