Experimental studies on vapor-liquid- solid three-phase flow boiling heat transfer and overall pressure drop of ethanol-water binary mixtures in a vertical tube with solid particles added were carried out. Based on the analysis of the heat transfer characteristics of this three-phase flow boiling, a mathematical model for predicting the three-phase flow boiling heat transfer coefficients of ethanol-water binary mixtures was developed. The results show that with the presence of inert solid particles in binary mixtures, flow boiling heat transfer is enhanced and is about twice that of vapor-liquid two-phase heat transfer. The predicted results of the flow boiling heat transfer coefficients of ethanol-water binary mixtures agreed well with the experimental data.