The systematic enhancement of value chains has become an important instrument in strategic investment projects. An effectively integrated toolset in this area is a critical factor for future competitiveness because it offers the ability to support the holistic alignment of people, work processes, tools and information flows across the organization. To achieve cross-functional alignment, the toolset has to encompass not only software tools and database architectures but also project workflow aspects. The modelling software has to offer realistic representations of constraints relevant to the chemical industry, be it linear, non-linear or purely rule-based from domain specific expertise. The database architecture has to provide a comprehensive data model that permits downloading of real-life data from ERP-systems as well as input from flexible sources for the purpose of what-if studies. Planning and scheduling functionalities are used to generate best-in-class production plans for the evaluation of design proposals on asset and storage capacity. In addition, discrete event simulation capabilities are required to evaluate the expected operational availability of the proposed value chain concept. This function is incorporating stochastic models of equipment failure as well as operational expertise. In combination, both approaches provide the necessary basis for reliable cost benefit analysis of strategic investments. Graphical editors for network layout and product flow are combined with powerful visualization tools such as Gantt-charts that encourage common understanding among project stakeholders. A systematic project workflow in connection with dedicated value improving practices provides the over-arching framework that guarantees organizational alignment and efficient usage of the toolset across all company functions.