The combined linear response coupled cluster/molecular mechanics (CC/MM) scheme including mutual polarization effects in the coupling Hamiltonian is applied together with supermolecular CC methods to the study of the gas-to-aqueous solution blue shift of the n -> pi* excitation energy in acetone. The aug-cc-pVDZ basis set is found to be adequate for the calculation of this excitation energy. In the condensed phase, the shift in the excitation energy is obtained by statistical averaging over 800 solute-solvent configurations extracted from a molecular dynamics simulation. We find the shift to be around 1100- 1200 cm(-1) depending on the specific model used to describe solvent polarization. The importance of including explicit polarization in both the molecular dynamics simulation as well as the COMM calculations is emphasized. Furthermore, the significant dependence of the excitation energy on the CO bond length of acetone is discussed.