A new reactor is proposed for the chemical derivation of aqueous starch solutions based on the application of static mixers. In a novel approach, heat transfer in the static mixer was modelled using the Pseudohomogeneous Two-dimensional Heat Transfer (PTHT) model. Experimental results show the suitability of this model for describing both axial and radial temperature gradients in the static mixer. Conversions of propylene oxide in the reactor were calculated using a two-dimensional reactor model. Experimental results are in excellent agreement with model calculations.