Approaches to control selectivity and activity in the catalytic reductive amination of butyraldehyde with ammonia over carbon supported noble metal catalysts (Ru, Rh, Pd, and Pt) were explored. Detailed analysis of the reaction network shows that the Schiff base N-[butylidene]butan-1-amine is the most prominent initial product and, only after nearly all butyraldehyde had been converted to N-[butylidene]butan-1-amine, amines are detected in the product mixture. From this intermediate, good hydrogenolysis catalysts (Ru, Rh) produce mostly butylamine, while catalysts less active in hydrogenolysis (Pd, Pt) lead to the hydrogenation of N-[butylidene]butan-1-amine to mostly dibutylamine.