A convenient and effective impregnation method was found to prepare Rh-Mn-Li/SiO2 catalyst by using large granularity of silica as support, of which Rh particle size is at 2-4 nm with narrow distribution and the number of it accessible for reagents is enhanced. As expected, the space-time yield (STY) and selectivity of C(2+)oxygenates were significantly increased from 338.6 g/kg-cat.h, 49.2% to 618.4 g/kg-cat.h, 54.6% respectively, when 14-20 mesh, instead of 20-40 mesh of silica, was employed.