This article presents comparative analysis between the classical PI (proportional-integral control) and MPC (model predictive control) techniques for a drying process on spouted beds. The on-line experimental setups were carried out in a laboratory-scale plant of a spouted bed dryer. The main objective was to optimize the plant operation by searching for the best control structure to be used in future scale enlargement. The major drawbacks encountered in this kind of system were high interactivity among variables, a malfunction as a result of calculated variables out of the operational window, and modeling mismatch. Despite the robustness of the operational PI, the control actions of this strategy did not overcome the variable interactions. The DMC (dynamic matrix control) and the QDMC (quadratic dynamic matrix control) algorithms performed satisfactorily over the major drawbacks. Special attention was given to the latter algorithm due to its ability to hold the variables under constrained oscillations. However, the best results were found for the adaptive GPC (generalized predictive control) algorithm whose actions prevailed over the modeling mismatch due to the strong nonlinear behavior intrinsic to the process. The main goal of the present work is to describe a procedure that can be standardized for other types of dryers and different scales. This is especially the case for the adaptive GPC, whose control structure is independent of the dryer nature and scale and whose implementation does not require previous identification procedures (self-tuning) and/or structural changes.