In this paper, a new methodology for the conceptual design of chromatographic reactors is proposed and illustrated for ester hydrolysis reactions in a fixed-bed chromatographic reactor with a pulse injection of the ester. In the first step, an extended equilibrium theory approach for chromatographic reactors is used to study the feasibility, i.e., to clarify whether total conversion of the reactant and total separation of the products are possible. In the second step, the required column length is calculated using a rate based model, which takes into account the finite reaction kinetics and axial dispersion. Finally, the theoretical predictions are compared with the experimental results.