In response to the ever increasing demand for smaller and lighter high-performance cooling devices, steady laminar liquid nanofluid flow in microchannels is simulated and analyzed. Considering two types of nanofluids, i.e., copperoxide nanospheres at low Volume concentrations in water or ethylene glycol, the conjugated heat transfer problem for microheat-sinks has been numerically solved. Employing new models for the effective thermal conductivity and dynamic viscosity of nanofluids, the impact of nanoparticle concentrations in these two mixture flows on the microchannel pressure gradients, temperature profiles and Nusselt numbers are computed, in light of aspect ratio, Viscous dissipation, and enhanced temperature effects. Based on these results, the following can be recommended for microheat-sink performance improvements: Use of large high-Prandtl number carrier fluids, nanoparticles at high volume concentrations of about 4% with elevated thermal conductivities and dielectric constants very close to that of the carrier fluid, microchannels with high aspect ratios, and treated channel walls to avoid nanoparticle accumulation. (c) 2005 Elsevier Ltd. All rights reserved.