This article deals with the output regulation of nonminimum-phase systems subject to input and output constraints. Through the off-line static data reconciliation algorithm for a class of stable nonlinear bioreactors, the static feedforward control can ensure constant disturbance attenuation in spite of input multiplicities and actuators constraints. Under the pseudo-steady-state error diagnoses and a graphics-based mechanism for disturbance estimation, the proposed error feedback control scheme will induce the piecewise output regulation. Based on the "intelligent" algorithm for tuning improvement, the closed-loop simulation shows that the piecewise control strategy turns out to be robust against the unknown disturbances.