Saline effluent from the glucose industry can be reused as resin regenerants after treatment by a bipolar membrane electrodialysis process preceded by chromatographic decalcification. Ca2+/Na+ isotherms measured on two weak acidic resins showed that the chelating resin has a higher selectivity for calcium. The decalcification process was optimized by combining rough decalcification on a carboxylic resin, followed by a finishing step on a chelating one. This chromatographic system led to the expensive chelating resin being spared and to the treatment of 60% more volume of effluent than with the carboxylic resin alone.