The contribution will show the first results from calorimetric screening of novel catalysts. Biotemplated platinum nanoclusters were prepared on the basis of S-layer-bacterial surface proteins-on different supports. Methods were contrived and examined, permitting both the investigation of catalytic bulk material, and the investigation of sensory interesting coatings. The calorimetric measurements were carried out using conventional calorimetric technique (DSC 111, firm SETARAM) and miniaturized calorimetric systems (integrated circuit calorimeter - IC-calorimeter and a sensor platform). The results of the calorimetric investigations to the selected model reactions (oxidation of hydrogen, carbon monoxide and propane) demonstrate the interesting characteristics of these new catalysts. (C) 2005 Elsevier B.V. All rights reserved.